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Sustained research productivity in accounting: a study of the senior cohort. Global Perspectives on Accounting Education , V. The impact of training of university teachers on their teaching skills , their approach to teaching and the approach to learning of their students.

Active Learning in Higher Education , pp. Life cycle productivity in academic research: Evidence from cumulative publication histories of academic economists. Southern Economic Journal , V. Beesley , Raymond L. Miller , and Terry M. Faculty motivation to do research: across disciplines in research extensive universities.

The Journal of the Professoriate , pp. Teacher training , teacher quality and student achievement. Journal of Public Economics , V. The relationship between research and teaching-a metaanalysis. Review of Educational Research , V. Lecturer self-efficacy , research skills , and publication output. Professor qualities and student achievement. The Review of Economics and Statistics , V.

Grandon Gill. Is faculty research productivity: Influential factors and implications. Information Resources Management Journal , V. Principals as agents: subjective performance measurement in education. Journal of Labour Economics , pp. Part-time or contingent community college faculty and the desire for full-time tenure track positions.

The Journal of Higher Education , V. Kevin Eagan. Educational Policy , V. Class size and achievement in introductory economics: evidence from the tuce iii data. Journal of Economic Education , pp. The impact of research productivity on early retirement of university professor. Industrial Relations , V. Research productivity over the life cycle: evidence for academic scientist. American Economic Review , V. The Firm as a Pool of Factor Complementarities.

Who succeeds at university? Factors predicting academic performance in first year Australian university students. The relation between research productivity and teaching effectiveness: complementary , antagonistic or independent constructs? The Journal of Higher Education , pp. Review of Business Management , V. Improving productivity: What faculty thinks about it—and its effect on quality. Change , pp. Are more senior academics really more research productive than junior academics?

Evidence from Australian law schools. Scientometrics , In press. Perceptions of the teaching-research nexus: A framework for analysis. Research in Higher Education , V. Journal of Econometrics , pp. Felder , and Rebecca Brent.

Does faculty research improve undergraduate teaching? An analysis of existing and potential synergies. Journal of Engineering Education , V. Managing the effective university. Higher Education Research and Development , pp. Association between research and teaching in Aus-tralian higher education. Higher Education , pp.

American Educational Research Journal , V. Latent root regression: An alternate procedure for estimating parameters in the presence of multicollinearity. Journal of Marketing Research , V. Hardiness commitment , gender , and age differentiate university academic performance. British Journal of Educational Psychology , V. Industrial and Corporate Change , V. Teaching norms and publication productivity.

New Directions for Institutional Research , pp. Studies in Higher Education , pp. Research productivity and student evaluation of teaching in social science classes: a research note. Faculty rank system , research motivation , and faculty research productivity: Measurement refinement and theory testing.

Estimation of relationships for limited dependent variables. Econometrica: journal of the Econometric Society , no 1 , pp. Faculty time allocations and research productivity. The Review of Higher Education , V. How effective are they? Exploring the impact of contingent faculty on undergraduate education. Changes in higher education and valuing the job: The views of accounting academics in Australia.

Journal of Higher Education Policy and Management , pp. Economies of scope in research and teaching: a non-parametric investigation. Academy of Management Learning and Education, V. Journal of Labor Economics, V. Implications of external research quality assessment for local research leadership: Learning Subject Geographic: Lat: 06 15 00 N degrees minutes Lat: 6.

Hepatitis E virus transmission from wild boar meat. Association of Guillain-Barre syndrome and hepatitis E infection. Hepatitis E is an autochthonous disease in industrialized countries. Analysis of 23 patients in South-West France over a month period and comparison with hepatitis A. Protracted viremia during acute sporadic hepatitis E virus infection. Hepatitis E infection in children: study of an outbreak. Cryoglobulinaemia and hepatitis C infection. Duration of viraemia and faecal viral excretion in acute hepatitis E.

Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Hepatitis E in Italy: A silent presence. Case of acute hepatitis E with concomitant signs of autoimmunity. Extrahepatic manifestations of hepatitis E virus. Response to: 'Chronic genotype 1 hepatitis E infection from immunosuppression for ileo-colonic Crohn's disease'.

Outcome of hepatitis E virus infection in patients with inflammatory arthritides treated with immunosuppressants: a French retrospective multicenter study. Hepatitis E virus quasispecies and the outcome of acute hepatitis E in solid-organ transplant patients. Hepatitis E virus: advances and challenges. The role of hepatitis E virus testing in drug-induced liver injury. Reactive arthritis. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial.

Asymptomatic acute hepatitis E in a female patient with ulcerative colitis. Clinical connection between rheumatoid arthritis and liver damage. The Clinical Perspective on Hepatitis E. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Chronic hepatitis E in the immunosuppressed: a new source of trouble?

Florian Bihl, Francesco Negro. Acute polyarthritis revealing hepatitis E. Management of viral hepatitis in patients with haematological malignancy and in patients undergoing haemopoietic stem cell transplantation: recommendations of the 5th European Conference on Infections in Leukaemia ECIL


The NMR plasma profiles of non-survivors were attributed to reduced phosphatidylcholines and lipid resonances, with increased lactate, tyrosine, methionine and phenylalanine signal intensities. Histological examination of liver tissue from DC patients confirmed increased hepatocyte cell death compared to controls.

Cross liver sampling at time of liver transplantation demonstrated that hepatic endothelial beds are a source of increased circulating total cytokeratin in DC. LPC and amino acid dysregulation is associated with increased mortality and severity of disease reflecting hepatocyte cell death. You are not logged in. Sign Up or Log In to join the discussion. Use Read by QxMD to access full text via your institution or open access sources.

Read also provides personalized recommendations to keep you up to date in your field. By using this service, you agree to our terms of use and privacy policy. Login Sign Up. Get Started. Discussion You are not logged in. Development of an accurate index for predicting outcomes of patients with acute liver failure. Serum 1H-NMR metabolomic fingerprints of acute-on-chronic liver failure in intensive care unit patients with alcoholic cirrhosis.

Application of this novel approach to IBD patients is particularly useful for two reasons. First, we could confirm that the associations of most known clinical risk factors with vitamin D deficiency were indeed independent of seasonal variability and could be confirmed after normalization of 25 OH D concentrations as well as by analysis of independent risk factors by multiple regression.

Second, sinusoidal regression may be useful to better interpret the results of 25 OH D testing in the clinic, since seasonal variations can be taken into account. Moreover, physicians could adjust the 25 OH D concentration with respect to the date of blood draw which would allow a better estimate of the respective vitamin D status.

Current thresholds are derived from recommendations for prevention of osteoporosis and do not necessarily apply to IBD-related risk factors. It is obvious that ongoing vitamin D supplementation protected against vitamin D deficiency. However, our data indicate that only a minority of deficient patients achieve a normalization of their 25 OH D concentrations. Therefore, there is a clear need for better and repeated measures of patient education.

Several findings indicate that vitamin D has anti-inflammatory effects on the immune system [ 4 , 28 ] and it was shown to inhibit pro-inflammatory TH1 and TH17 cytokine production in CD patients in vivo [ 29 ]. The question whether vitamin D deficiency is cause or consequence of disease activity remains enigmatic.

Moreover, clinical trials addressing the impact of vitamin D supplementation on IBD disease outcomes have yielded conflicting results [ 30 — 33 ], which may also be affected by implementing a suboptimal trial design [ 34 ]. Our finding that CD patients with improved disease activity at follow-up also had significantly increased 25 OH D concentrations is in favor of the hypothesis that vitamin D indeed exerts protective and anti-inflammatory effects.

The impact of vitamin D on immune cell function as well as therapeutic application of vitamin D to affect clinically meaningful IBD outcomes should therefore be addressed in prospective trials. Our data indicate that the risk to develop vitamin D deficiency is mainly determined by these seasonal factors, patient compliance as well as disease activity. Moreover, improved disease activity of CD patients over time was associated with increasing serum 25 OH D concentrations.

We wish to thank J. Schiefele for providing a list of outpatients with IBD diagnosis, D. Rockus for providing 25 OH D test results of the control cohort, Dr. Graf and Dr. Binder for help with statistical analysis. Browse Subject Areas? Click through the PLOS taxonomy to find articles in your field. Abstract Objectives Vitamin D deficiency predicts unfavorable disease outcomes in inflammatory bowel disease. Methods Univariable and multiple regression analyses were performed in a retrospective cohort of patients to determine risk factors for vitamin D deficiency.

Introduction The fat-soluble vitamin D is absorbed in the small intestine or endogenously synthesized in the skin in response to ultraviolet B ray UVB exposure. Materials and methods Study design A retrospective chart review of outpatient IBD patients treated at Freiburg University Hospital between January and December was performed. Results High prevalence rates of vitamin D deficiency in IBD patients consecutive patients with at least one documented analysis of their 25 OH D serum concentration were identified by retrospective chart review.

Download: PPT. Specific CD-related risk factors Subgroup analysis of CD patients following normalization for seasonal variability revealed that moderate disease activity vs. Fig 2. Impact of vitamin D supplementation on disease outcomes Patients with documented vitamin D deficiency had a higher probability to receive a prescription for vitamin D OR 6. Conclusions 25 OH D concentrations of IBD patients are strongly influenced by seasonal factors, which can be predicted for every day of the year by a sinus curve-based algorithm.

Supporting information. S1 Fig. S1 Table. Univariable regression analysis of associations between clinical parameters of pooled CD and UC patients with vitamin D deficiency. S2 Table. Univariable regression analysis of associations between clinical parameters of CD patients with vitamin D deficiency. S3 Table. Univariable regression analysis of associations between clinical parameters of UC patients with vitamin D deficiency.

Acknowledgments We wish to thank J. References 1. Gubatan J, Moss AC. Vitamin D in inflammatory bowel disease: more than just a supplement. Current opinion in gastroenterology. Inflammatory bowel disease. Annual review of immunology. Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls.

Journal of digestive diseases. View Article Google Scholar 5. Higher predicted vitamin D status is associated with reduced risk of Crohn's disease. Inflammatory bowel diseases. The American journal of gastroenterology. Normalization of plasma hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease. Vitamin D deficiency in Crohn's disease and healthy controls: a prospective case-control study in the Netherlands.

View Article Google Scholar Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population. Scandinavian journal of gastroenterology. Vitamin D levels in adults with Crohn's disease are responsive to disease activity and treatment. Active Crohn's disease is associated with low vitamin D levels. Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective.

World journal of gastroenterology. Digestive diseases and sciences. Vitamin D deficiency in Crohn's disease: prevalence, risk factors and supplement use in an outpatient setting. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN Journal of parenteral and enteral nutrition. Higher hydroxyvitamin D levels are associated with greater odds of remission with anti-tumour necrosis factor-alpha medications among patients with inflammatory bowel diseases.

Photochem Photobiol. Seasonal variation of serum hydroxyvitamin D levels in adult patients with inflammatory bowel disease. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. Periodicity of hospital admissions for inflammatory bowel disease. A simple index of Crohn's-disease activity. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.

The Journal of clinical endocrinology and metabolism. Seasonal variations of OH vitamin D serum levels are associated with clinical disease activity in multiple sclerosis patients. Journal of the neurological sciences. Raftery T, O'Sullivan M.

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Lancet Oncol. Sengsayadeth, S. Bone Marrow Transplant. Serve, H. Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial. Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia SORAML : a multicentre, phase 2, randomised controlled trial.

Metzelder, S. High activity of sorafenib in FLT3-ITD-positive acute myeloid leukemia synergizes with allo-immune effects to induce sustained responses. Leukemia 26 , — Tschan-Plessl, A. Chen, Y. Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for Fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia. Blood Marrow Transplant. Antar, A. Sorafenib maintenance appears safe and improves clinical outcomes in FLT3-ITD acute myeloid leukemia after allogeneic hematopoietic cell transplantation.

Lymphoma Myeloma Leuk. Tarlock, K. Blood Cancer 62 , — Brunner, A. Haematopoietic cell transplantation with and without sorafenib maintenance for patients with FLT3-ITD acute myeloid leukaemia in first complete remission. Zorko, N. Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias.

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Romieu-Mourez, R. Cancer Res. Liang, Q. Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses. Smith, C. Leukemia 29 , — Buck, M. T cell metabolism drives immunity. Immunity 36 , 68—78 CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.

USA , — Schultze-Florey, C. TCR diversity is a predictive marker for donor lymphocyte infusion response. Blood , Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response. Thiant, S. Sauter, C. Interleukin administration increases graft-versus-tumor activity in recipients of haploidentical hematopoietic SCT.

Chen, G. Expanded donor natural killer cell and IL-2, IL treatment efficacy in allogeneic hematopoietic stem cell transplantation. Blaser, B. Donor-derived IL is critical for acute allogeneic graft-versus-host disease. Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity.

Roychowdhury, S. IL but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease. Cario, G. High interleukin expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS. Wu, S. Expression of interleukin 15 in primary adult acute lymphoblastic leukemia. Cancer , — Nasilowska-Adamska, B. Mild chronic graft-versus-host disease may alleviate poor prognosis associated with FLT3 internal tandem duplication for adult acute myeloid leukemia following allogeneic stem cell transplantation with myeloablative conditioning in first complete remission: a retrospective study.

Barnes, B. Steinmann, J. Bejanyan, N. Survival of patients with acute myeloid leukemia relapsing after allogeneic hematopoietic cell transplantation: a center for international blood and marrow transplant research study. Takami, A. Donor lymphocyte infusion for the treatment of relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation.

Mitochondrial dynamics controls T cell fate through metabolic programming. Cell , 63—76 Bolger, A. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30 , — Li, H. Fast and accurate long-read alignment with Burrows—Wheeler transform. Bioinformatics 26 , — McKenna, A. Genome Res. Lek, M. Analysis of protein-coding genetic variation in 60, humans. Nature , — Boeva, V. Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data.

Bioinformatics 28 , — Carvalho, B. A framework for oligonucleotide microarray preprocessing. Luo, W. GAGE: generally applicable gene set enrichment for pathway analysis. BMC Bioinformatics 10 , Kamburov, A. The ConsensusPathDB interaction database: update. Nucleic Acids Res. Brummer, T. Therefore, we aimed to describe this burden in patients with haematological malignancies, including those receiving allogeneic haematopoietic stem cell transplantation.

Methods: We conducted a retrospective, multicentre cohort study across 11 European centres and collected clinical characteristics of 50 patients with haematological malignancy and RNA-positive, clinically overt hepatitis E between April and March Immunosuppressive treatment reductions were associated with mortality in 2 patients Conclusion: Hepatitis E is associated with mortality and liver-related morbidity in patients with haematological malignancy.

Blood-borne transmission contributes to the burden. Ribavirin should be initiated early, whereas reduction of immunosuppressive treatment requires caution.

Portal vein thrombosis PVT is an important cause of noncirrhotic portal hypertension.

Dominik bettinger west We therefore established a model to predict dominik bettinger west 25 OH D serum concentration for any given day of the year in both, patients with IBD from our retrospective cohort as well as an independent large local reference population using a ayomide abetting regression analysis. Contrasting perspectives on the relationship between teaching and research. Make the most of Read. Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls. Title: Targeted Oncology. Moreover, patients with moderate disease activity had significantly lower corrected absolute 25 OH D concentrations as compared to patients in remission while the difference for severe activity did not reach statistical significance Fig 2which may be influenced by the fact that the number of patients with severe activity was rather limited in this outpatient cohort.
Dominik bettinger west After normalization of 25 OH D concentrations for the day of analysis, vitamin D deficiency was associated with histories of complications dominik bettinger west to inflammatory bowel disease, surgery, smoking and ongoing diarrhea betfred sportsbook betting in florida initial disease manifestation during adulthood, ongoing vitamin D supplementation and diagnosis of ulcerative colitis vs. Authors: Adkins, Amy E. Springer Nature is supporting the global response to COVID by making all relevant content immediately and freely available. The impact of training of university teachers on their teaching skillstheir approach to teaching and the approach to learning of their students. Economics of Education ReviewV.
Binary options strategy using moving averages for day trading Acute transverse myelitis new betting sites csgo hepatitis E virus infection. Save your favorite articles in one place with a free QxMD account. We focused the analysis of 25 OH D concentrations on disease activity of CD patients given the rather limited numbers of patients with UC. Login Sign Up. Comment on this article Sign in to comment. Such seasonal variability with lower 25 OH D concentrations in winter has been demonstrated in some studies [ 14 — 1622 ], but not in others [ 1117 ]. Publication date Electronic : 17 November
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